At Foo Wo House on Wo Che Estate in Sha Tin, almost 20 percent of those tested were found to carry the virus.
Authorities said 309 out of 1,580 people tested there had Covid.
The Covid-positive rate among residents at three other public housing lockdowns was between about 12 and 16 per cent.
At Foo Wai House, on Sun Tin Wai Estate, 202 tested positive, while at Sau Ming House, on Sau Mau Ping Estate, 285 infections were found.
A separate lockdown at Shek Chun House, on Shek Lei Estate in Kwai Chung, turned up 208 cases.
Other lockdowns at Chun Lai House and Chun Yin House in Cheung Sha Wan saw a similar infection rate of about 13 percent, after 1,980 people were tested.